Cell size and growth rate are major determinants of replicative lifespan
Volume 10, Issue 1
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January 1, 2011
Pages 144 - 155http://dx.doi.org/10.4161/cc.10.1.14455
Authors: Jingye Yang, Huzefa Dungrawala, Hui Hua, Arkadi Manukyan, Lesley Abraham, Wesley Lane, Holly Mead, Jill Wright and Brandt L. Schneider View affiliations
Yeast cells, like mammalian cells, enlarge steadily as they age. Unabated cell growth can promote cellular senescence; however, the significance of the relationship between size and cellular lifespan is not well understood. Herein, we report a genetic link between cell size, growth rate and lifespan. Mutations that increase cell size concomitantly increase growth rate and decrease lifespan. As a result, large cells grow, divide and age dramatically faster than small cells. Conversely, small cell mutants age slowly and are long-lived. Investigation of the mechanisms involved suggests that attainment of a maximal size modulates lifespan. Indeed, cumulative results revealed that life expectancy is size-dependent, and that the rate at which cells age is determined in large part by the amount of cell growth per generation.