Review of Concept
Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal
Volume 9, Issue 24
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December 15, 2010
Pages 4788 - 4794http://dx.doi.org/10.4161/cc.9.24.14360
Authors: Mikhail V. Blagosklonny View affiliations
Although we do not know everything about aging, we now know enough to start its pharmacologic suppression using clinically approved drugs. Aging turns out to be driven by sensing-signaling pathways (such as the mTOR pathway). Given that some inhibitors of the mTOR pathway are already in clinical use, there is a unique opportunity to suppress aging, while treating and preventing diseases. By itself this will answer some burning questions in gerontology. Here I discuss a proposal, starting from retrospective clinical studies to animal and cellular models to drug screens in order to develop non-toxic and effective schedules and drug combinations for extending healthy life span in our lifetime.