Review of Concept

Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal 

Volume 9, Issue 24   December 15, 2010
Pages 4788 - 4794
http://dx.doi.org/10.4161/cc.9.24.14360
Authors: Mikhail V. Blagosklonny

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Abstract:
Although we do not know everything about aging, we now know enough to start its pharmacologic suppression using clinically approved drugs. Aging turns out to be driven by sensing-signaling pathways (such as the mTOR pathway). Given that some inhibitors of the mTOR pathway are already in clinical use, there is a unique opportunity to suppress aging, while treating and preventing diseases. By itself this will answer some burning questions in gerontology. Here I discuss a proposal, starting from retrospective clinical studies to animal and cellular models to drug screens in order to develop non-toxic and effective schedules and drug combinations for extending healthy life span in our lifetime.

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