Sign up for Table of Contents Alerts.
Email this page
Print this page
Extra Views
Immunological Consequences of Macrophage-Mediated Clearance of Apoptotic Cells
Aunjung Kim, Elaine Y. Chung and Xiaojing Ma
volume 4 | issue 2
february 2005Pages: 231 - 234
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
Apoptosis and the rapid clearance of apoptotic cells by professional or non-professional phagocytes are normal and coordinated processes that ensure controlled cell growth with a non-pathological outcome. Defects in clearance of apoptotic cells by macrophages have serious consequences often resulting in autoimmune disorders. Phagocyte-derived immunoregulatory cytokines such as Interleukin-12 and Interleukin-10 play pivotal roles in the etiology and pathology of many autoimmune diseases. Elucidation of the apoptotic cell-mediated signaling mechanisms involved in the control of pro- and anti-inflammatory cytokines during cell turnovers under normal and pathological conditions may help us counter the cytokine dysregulation and control inappropriate host immune reactions in pathological situations such as autoimmunity, infectious diseases, graft-versus-host disease, and cancer.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.