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Epigenetic Plasticity of Hematopoietic Cells
Constanze Bonifer
volume 4 | issue 2
february 2005Pages: 211 - 214
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In recent years significant evidence was provided for the concept that the developmental potential is engraved in the chromatin of stem cells. This is indicated by low-level expression of lineage specific genes and also by epigenetic alterations that occur prior to gene locus activation. In turn, cell lineage specification involves not only the activation, but also the epigenetic silencing of different genetic programmes. In this article, I will summarise recent data from my laboratory that indicate that (i) at the epigenetic level developmental processes occur in a step-wise fashion and (ii) that developmental windows exist, which are associated with a specific chromatin structure, in which such decisions can be reversed.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.