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Brief Report
Two-Faced Cyclins with Eyes on the Targets
Vincent Archambault, Nicolas E. Buchler, Gwendolyn M. Wilmes, Matthew D. Jacobson and Frederick R. Cross
volume 4 | issue 1
january 2005Pages: 125 - 130
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We recently reported that the ‘hydrophobic patch’ (HP) of the Saccharomyces cerevisiae S-phase cyclin Clb5 facilitates its interaction with Orc6 (via its Cy or RXL motif), providing a mechanism that helps prevent re-replication from individual origins.1 This is the first finding of a biological function for an interaction between a cyclin and a cyclin-binding motif (Cy or RXL motif) in a target protein in Saccharomyces cerevisiae. It is also the first such example involving a B-type cyclin in any organism. Yet, some of our observations as well as work from other groups suggest that HP-RXL interactions are functionally important for cyclin-Cdk signaling to other targets. The evolutionary conservation of the HP motif suggests that it allows cyclins to carry out important and specialized functions.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.