APC/C-Cdh1: From cell cycle to cellular differentiation and genomic integrity
Volume 9, Issue 19
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October 1, 2010
Pages 3934 - 3942http://dx.doi.org/10.4161/cc.9.19.13585
Authors: Xinxian Qiao, Liyong Zhang, Armin M. Gamper, Takeo Fujita and Yong Wan View affiliations
Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of cell cycle. The activation of APC/C is depended on two WD-40 domain proteins, Cdc20 and Cdh1. While APC/Cdc20 principally regulates mitotic progression, APC/Cdh1 shows a broad spectrum of substrates in and beyond cell cycle. In past several years, numerous biochemical and mouse genetic studies have greatly attracted our attention to the emerging role of APC/Cdh1 in genomic integrity, cellular differentiation and human diseases. This review will aim to summarize the recent expended understanding of APC/Cdh1 in regulating biological function and how its dysfunction may lead to diseases.