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Replication Timing of Human Chromosome 6
Kathryn Woodfine, David M. Beare, Koichi Ichimura, Silvana Debernardi, Andrew J. Mungall, Heike Fiegler, V. Peter Collins, Nigel P. Carter and Ian Dunham
volume 4 | issue 1
january 2005Pages: 172 - 176
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Genomic microarrays have been used to assess DNA replication timing in a variety of eukaryotic organisms1-3. A replication timing map of the human genome has already been published at a 1Mb resolution3. Here we describe how the same method can be used to assess the replication timing of chromosome 6 with a greater resolution using an array of overlapping tile path clones. We report the replication timing map of the whole of chromosome 6 in general, and the MHC region in particular. Positive correlations are observed between replication timing and a number of genomic features including GC content, repeat content and transcriptional activity.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.