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Epithelial-Mesenchymal Transition: NF-κB Takes Center Stage
Margit A. Huber, Hartmut Beug and Thomas Wirth
volume 3 | issue 12
december 2004Pages: 1477 - 1482
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Activation of the transcription factor NF-?B occurs in many human tumors, and studies have shown that NF-κB can promote cell proliferation and oncogenesis, possibly by protecting cells from apoptosis. Little is known, however, about whether NF-κB is involved in tumor progression including epithelial-mesenchymal transition (EMT), a central process governing both morphogenesis and carcinoma progression in multicellular organisms. In a combined in vitro/in vivo model of mammary carcinogenesis, NF-κB was essential both for the induction and maintenance of EMT and for in vivo metastasis. NF-κB and the signaling pathways that are involved in its activation should therefore receive attention as potential targets for the development of novel anti-metastatic cancer treatments.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.