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CYCLINg through transcription: Post-translational modifications of P-TEFb regulate transcription elongation

Volume 9, Issue 9   May 1, 2010
Pages 1697 - 1705
http://dx.doi.org/10.4161/cc.9.9.11346
Authors: Sungyoo Cho, Sebastian Schroeder and Melanie Ott

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Abstract:
The cyclin T/CDK9 complex, also called positive transcription elongation factor b (P-TEFb) phosphorylates the C-terminal domain of the large fragment of the RNA polymerase II. This action is a hallmark of the transition from transcription initiation to elongation. P-TEFb is itself modified by phosphorylation and ubiquitination. Recently, the core components of P-TEFb, cyclin T1 and the CDK9 proteins, were identified as novel substrates of histone acetyltransferases. Here, we review how posttranslational modifications regulate the activity of the P-TEFb complex and discuss how acetylation of the complex optimizes transcription elongation in the context of other posttranslational modifications.

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