Table of Contents

Volume 6, Issue 9

  September 2007

  Pages 1333 - 1510

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Editor's Corner

• Cover Image

  
  

News

• Identification of Mutations in LKB1 and a Role for the Gene in Suppression of Lung Cancer

  
  Pages 1333 - 1334

• Molecular Links Between IKKbeta, TSC1, mTOR and VEGF Provide Mechanism of Crosstalk Between Inflammatory Pathway and Angiogenic Switch

  
  Pages 1333 - 1334

• Novel Oncogenic Gene Fusions in Prostate Cancer

  
  Pages 1333 - 1334

• MiRNA34, Regulated by p53, is Lost in Lung Cancer

  
  Page 1333

• Does Everyone Need a Genetic Test Before Taking Irinotecan?

  
  Pages 1333 - 1334

• Splice Variant of XBP1, an Estrogen Receptor-Interacting Protein, is Linked to Tamoxifen Resistance

  
  Pages 1333 - 1334

• Does Blocking VEGF from the Inside or the Outside of the Cell Make a Difference?

  
  Pages 1333 - 1334

• Death Proteins Required for T-cell Maturation Promote Cell Proliferation and Mitochondrial ROS Production

  
  Page 1333

• Diabetes Drug Metformin Activates AMPK, Increases Glycolysis, Inhibits Oxidative Phosphorylation and Selectively Reduces Growth of p53-Deficient Tumors in Mice

  
  Page 1333

• Five New Research Programs to Receive Funding from the Samuel Waxman Cancer Research Foundation

  
  Pages 1334 - 1335

• Novel Method Developed to Study Blood Vessels in Disease State

  
  Pages 1336 - 1337

Review

• Cell Cycle Arrest by Glucocorticoids May Protect Normal Tissue and Solid Tumors from Cancer Therapy

  Jürgen Mattern, Markus W. Büchler and Ingrid Herr
  Pages 1338 - 1347

Journal Club

• MDA-MB-435: The Questionable Use of a Melanoma Cell Line as a Model for Human Breast Cancer is Going On

  Matthias Christgen and Ulrich Lehmann
  Pages 1348 - 1350

• Androgen Receptor Modulation: Lessons Learned from Beyond the Prostate

  Nima Sharifi and William D. Figg
  Pages 1351 - 1352

Clinical Study

• Preclinical and Clinical Studies With the Multi-Kinase Inhibitor CEP-701 as Treatment for Prostate Cancer Demonstrate the Inadequacy of PSA Response as a Primary Endpoint

  Connie Collins, Michael A. Carducci, Mario A. Eisenberger, John T. Isaacs, Alan W. Partin, Roberto Pili, Victoria J. Sinibaldi, Janet S. Walczak and Samuel R. Denmeade
  Pages 1353 - 1360

Clinical Case Report

• Irinotecan Chemotherapy During Valproic Acid Treatment: Pharmacokinetic Interaction and Hepatotoxicity

  Floris A. de Jong, Jessica M. van der Bol, Ron H. J. Mathijssen, Walter J. Loos, Ron A.A. Mathot, Jos J.E.M. Kitzen, Martin J. van den Bent and Jaap Verweij
  Pages 1361 - 1367

Research Papers

• PKCη Expression Contributes to the Resistance of Hodgkin's Lymphoma Cell Lines to Apoptosis

  Sara Abu-Ghanem, Galia Oberkovitz, Daniel Benharroch, Jacob Gopas and Etta Livneh
  Pages 1368 - 1373

• Anti-Proliferative Effect of Ursolic Acid on Multidrug Resistant Hepatoma Cells R-HepG2 by Apoptosis Induction

  Dong-Mei Zhang, Patrick Ming-Kuen Tang, Judy Yuet-Wa Chan, Hung-Ming Lam, Shannon Wing-Ngor Au, Siu-Kai Kong, Stephen Kwok-Wing Tsui, Mary Mui-Yee Waye, Thomas Chung-Wai Mak and Kwok-Pui Fung
  Pages 1374 - 1382

• Systemic and Skin Toxicity in Cercopithecus aethiops sabaeus Monkeys Treated During 26 Weeks with a High Intravenous Dose of the Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Nimotuzumab

  Maria Elene Arteaga, Nuris Nuris Ledon, Angel Casaco, Balia Pardo, Miriam Garcia, Magela Boleda, Lisel Vina, Romy Orphee, Osvaldo Hernandez, Consuelo Gonzalez, Dasha Fuentes, Valia Rodriguez, Lidia Charro, Farah Baro, Amparo Macias, Aylen Perez, Yakelin Morales, Nelvys Subiros, Barbara Gonzalez, Mayra Ramos, Leyanis Rodriquez, Alcides Ballester-Labrada and Tania Crombet
  Pages 1383 - 1388

• Single-Photon Emission Computed Tomography Imaging With a Humanized, Apoptosis-Inducing Antibody Targeting Human Death Receptor 5 in Pancreas and Breast Tumor Xenografts

  Hyunki Kim, Tandra R. Chaudhuri, Donald J. Buchsbaum, Deli Wang and Kurt R. Zinn
  Pages 1389 - 1395

• Expression Changes in EZH2, But Not in BMI-1, SIRT1, DNMT1 or DNMT3B are Associated with DNA Methylation Changes in Prostate Cancer

  Michele J. Hoffmann, Rainer Engers, Andrea R. Florl, Arie P. Otte, Mirko Muller and Wolfgang A. Schulz
  Pages 1396 - 1405

• Anthracenedione Derivative 1403P-3 Induces Apoptosis in KB and KBv200 Cells Via Reactive Oxygen Species-Independent Mitochondrial Pathway and Death Receptor Pathway

  Jian-ye Zhang, Hai-ying Wu, Xue-kui Xia, Yong-ju Liang, Yan-yan Yan, Zhi-gang She, Yong-cheng Lin and Li-wu Fu
  Pages 1406 - 1414

• mDia Function is Critical for the Cell Suicide Program Triggered by Farnesyl Transferase Inhibition

  Uma Kamasani, James B. DuHadaway, Arthur S. Alberts and George C. Prendergast
  Pages 1415 - 1420

• Indomethacin Enhances the Cytotoxicity of Recombinant Human Lymphotoxin α on Tumor Cells by Suppressing NF-κB Signaling

  Yijun Shen, Tong Yang, Jing Wang, Qing Xu, Rong Li, Wei Pan, Gang Li, Zheng Wang, Jingwei Tan, Jinsong Wu, Fang Wu, Luochun Wang and Yanjun Liu
  Pages 1421 - 1426

• Bone Marrow Renin-Angiotensin System Expression In Polycythemia Vera And Essential Thrombocythemia Depends On JAK2 Mutational Status

  Maruska Marusic Vrsalovic, Vlatko Pejsa, Tajana Stoos Veic, Slobodanka Ostojic Kolonic, Radmila Ajdukovic, Visnja Haris, Ozren Jaksic and Rajko Kusec
  Pages 1427 - 1429

• Raf Inhibitor Stabilizes Receptor for the Type I Interferon But Inhibits its Anti-Proliferative Effects in Human Malignant Melanoma Cells

  K.G. Suresh Kumar, Jianghuai Liu, Ying Li, Duonan Yu, Andrei Thomas-Tikhonenko, Meenhard Herlyn and Serge Y. Fuchs
  Pages 1430 - 1434

• Correlation Between Hybrid 18F-FDG PET/CT and Apoptosis Induced by Neoadjuvant Chemotherapy in Breast Cancer

  Dong Li, Qing Yao, Liwen Li, Ling Wang and Jianghao Chen
  Pages 1435 - 1441

• VSL#3 Probiotic Treatment Reduces Chemotherapy-Induced Diarrhoea and Weight Loss

  Joanne M Bowen, Andrea M Stringer, Rachel J Gibson, Ann SJ Yeoh, Sarah Hannam and Dorothy MK Keefe
  Pages 1442 - 1447

• The Functional Effects of Acid Ceramidase Over-Expression in Prostate Cancer Progression and Resistance to Chemotherapy

  Antonio F. Saad, William D. Meacham, Aiping Bai, Viviane Anelli, Ayman E.M. Mahdy, Lorianne S. Turner, Joe Cheng, Alicja Bielawska, Jacek Bielawski, Thomas E. Keane, Lina M. Obeid, Yusuf A. Hannun, James S. Norris and Xiang Liu
  Pages 1448 - 1453

• Potentiation of the Antitumor Effects of Both Selective Cyclooxygenase-1 and Cyclooxygenase-2 Inhibitors in Human Hepatic Cancer Cells by Inhibition of the MEK/ERK Pathway

  Antonella Cusimano, Daniela Foderà, Natale D'Alessandro, Nadia Lampiasi, Antonina Azzolina, Giuseppe Montalto and Melchiorre Cervello
  Pages 1454 - 1461

• Diffusion-Weighted and Macromolecular Contrast Enhanced MRI of Tumor Response to Antivascular Therapy with ZD6126

  Jens Vogel-Claussen, Barjor Gimi, Dmitri Artemov and Zaver M. Bhujwalla
  Pages 1462 - 1468

• Lung Cancer: An Organized Cellular and Metabolic Domain

  Michael I. Koukourakis, Alexandra Giatromanolaki, Georgios Bougioukas and Efthimios Sivridis
  Pages 1469 - 1472

• Mutant TNF-α Negatively Regulates Human Breast Cancer Stem Cells from MCF7 in vitro

  Yaochen Li, Linghong Kong, Ye Yang and Kangsheng Li
  Pages 1473 - 1482

• Chemotherapy-Resistant Side-Population of Colon Cancer Cells has a Higher Sensitivity to TRAIL than the Non-SP, a Higher Expression of c-Myc and TRAIL-Receptor DR4

  Robyn T. Sussman, M. Stacey Ricci, Lori S. Hart, Shi Yong Sun and Wafik S. El-Deiry
  Pages 1483 - 1488

Workshop Report

• Tumor Cell Dormancy: An NCI Workshop Report

  Open Access Article

  Robert L. Vessella, Klaus Pantel and Suresh Mohla
  Pages 1489 - 1497

Profiles and Legacies

• Hasan Mukhtar

  
  Pages 1498 - 1501