Table of Contents

Volume 4, Issue 1

  January 2005

  Pages 1 - 127

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Editor's Corner

• Cover Image

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• Letter to the Editorial Board of Cancer Biology and Therapy

  Wafik S. El-Deiry
  Page 1

• Letter to the Editor: Androgens and Prostate Cancer: Are the Descriptors Valid?

  Pradip Roy-Burman, Donald J. Tindall, Diane M. Robins, Norman M. Greenberg, Mary J.C. Hendrix, Suresh Mohla, Robert H. Getzenberg, John T. Isaacs, Kenneth J. Pienta
  Pages 2 - 3

News

• BRAF and COX-2 as Targets for Therapy of Thyroid Cancer

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  Page 4

• Chronic Stress and Cancer Risk

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  Page 4

• Celebrex Triggers Death Receptors in Non-Small Cell Lung Cancer

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  Page 4

• Head and Neck Cancer Biomarkers Detected in Saliva

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  Page 4

• Stem Cells Attracted by Tissue Inflammation

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  Page 4

• Myeloid Progenitors Improve Survival of 5-FU-Treated Mice

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• Protein Phophorylation Mechanism Involving IP7 Instead of ATP Holds Clues for New Drugs

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  Page 4

• CCI-779 Effectively Targets mTOR in Prostate Tumors with Common PTEN Mutations

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  Page 4

• Differential Response to IL-4 Offers Clues to Therapy of Diffuse Lymphoma Subtypes

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  Page 4

Reviews

• The Thioredoxin Reductase/Thioredoxin System: Novel Redox Targets for Cancer Therapy

  John E. Biaglow, Richard A. Miller
  Pages 5 - 12

• The SERCA Pump as a Therapeutic Target: Making a “Smart Bomb” for Prostate Cancer

  Samuel R. Denmeade, John T. Isaacs
  Pages 13 - 21

Bedside to Bench Report

• Paraneoplastic Leukemoid Reaction and Rapid Progression in a Patient with Malignant Melanoma: Establishment of KT293, a Novel G-CSF-Secreting Melanoma Cell Line

  Bodo Schniewind, Matthias Christgen, Axel Hauschild, Roland Kurdow, Holger Kalthoff, Hans Jürgen Klomp
  Pages 22 - 26

Journal Club

• No One-Way Street: Cross-Talk Between E-cadherin and Receptor Tyrosine Kinase (RTK) Signaling—A Mechanism to Regulate RTK Activity

  Claudia D. Andl and Anil K. Rustgi
  Pages 27 - 30

Research Papers

• Prognostic Role of bcl-xL and p53 in Childhood Acute Lymphoblastic Leukemia

  Raffaele Addeo, Michele Caraglia, Alfonso Baldi, Velia D’Angelo, Fiorina Casale, Stefania Crisci, Alberto Abbruzzese, Mara Campioni, Maria Teresa Di Tullio, Paolo Indolfi
  Pages 31 - 37

• The Tumor Suppressor p33^ING1b Enhances Taxol-Induced Apoptosis by p53-Dependent Pathway in Human Osteosarcoma U2OS Cells

  Jin-Jun Zhu, Fo-Bao Li, Jun-Min Zhou, Zong-Chao Liu, Xiao-Feng Zhu, Wei-Ming Liao
  Pages 38 - 46

Commentary

• An Intact ING1-p53 Pathway Can Potentiate the Cytotoxic Effects of Taxol

  Igor Garkavtsev, Yves Boucher
  Pages 47 - 48

Research Papers

• Unpulsed Dendritic Cells Induce Broadly Applicable Anti-Tumor Immunity in Mice

  Grzegorz Dworacki, Vito R. Cicinnati, Susanne Beckebaum, Eva Pizzoferrato, Thomas K. Hoffmann, Albert B. De Leo
  Pages 49 - 55

• The Relationships between p53 Protein Expression and the Clinicopathological Features in the Uveal Melanomas

  Mahmoud R. Hussein
  Pages 56 - 58

• ZNRD1 Gene Suppresses Cell Proliferation through Cell Cycle Arrest in G1 Phase

  Liu Hong, Rui Shi, Lijun Sun, Xiaodong Shao, Yu Han, Zhen Chen, Dawei Huang, Shengjuan Hu, Yumei Zhang, Daiming Fan
  Pages 59 - 63

• Effects of HIV-1 Nef, a Cytotoxic Viral Protein, on the Growth of Primary Colorectal Cancer

  Harvey L. Bumpers, Ming-Bo Huang, Michael Powell, William E. Grizzle, James Lillard, Joel Okoli, Vincent C. Bond
  Pages 64 - 68

• The Chemokine Receptor CXCR4 is Regulated by DNA Methylation in Pancreatic Cancer

  Norihiro Sato, Hiroyuki Matsubayashi, Noriyoshi Fukushima, Michael Goggins
  Pages 69 - 75

• The Proteasome Inhibitor Bortezomib (PS-341) Inhibits Growth and Induces Apoptosis in Primary Effusion Lymphoma Cells

  Hittu Matta, Preet M. Chaudhary
  Pages 76 - 81

• Homozygous Deletion of the MTAP Gene in Invasive Adenocarcinoma of the Pancreas and in Periampullary Cancer: A Potential New Target for Therapy

  Steven R. Hustinx, Ralph H. Hruban, Lorenzo M. Leoni, Christine Iacobuzio-Donahue, John L. Cameron, Charles J. Yeo, Priscilla N. Brown, Pedram Argani, Raheela Asfaq, Noriyoshi Fukushima, Michael Goggins, Scott E. Kern, Anirban Maitra
  Pages 82 - 85

• The Glycolytic Inhibitor 2-deoxy-D-glucose Enhances the Efficacy of Etoposide in Ehrlich Ascites Tumor Bearing Mice

  Seema Gupta, Rohit Mathur, B S Dwarakanath
  Pages 86 - 93

• Efficacy of Beta-Lapachone in Pancreatic Cancer Treatment: Exploiting the Novel, Therapeutic Target NQO1

  Matthew Ough, Anne Lewis, Erik A. Bey, Jinming Gao, Justine M. Ritchie, William Bornmann, David A. Boothman, Larry W. Oberley, Joseph J. Cullen
  Pages 94 - 101

• Defining the Extent of Cables Loss in Endometrial Cancer Subtypes and its Effectiveness as an Inhibitor of Cell Proliferation in Malignant Endometrial Cells In Vitro and In Vivo

  Robert L. DeBernardo, Ramey D. Littell, Hongwei Luo, Linda R. Duska, Esther Oliva, Sandra D. Kirley, Maureen P. Lynch, Lawrence R. Zukerberg, Bo R. Rueda
  Pages 102 - 106

• DNA Ploidy and S Phase Fraction of Breast and Ovarian Tumor Cells Treated with a Natural Anthracycline Analog (Aloin)

  Amr Y. Esmat, Shadia M. El-Gerzawy, Amira Rafaat
  Pages 107 - 111

• Inhibition of Gastric Cancer Angiogenesis by Vector-Based RNA Interference for Raf-1

  Fanping Meng, Jie Ding, Na Liu, Jing Zhang, Xiaodong Shao, Huiqin Shen, Yan Xue, Huahong Xie and Fan Daiming
  Pages 112 - 116

• Antitumor Effect of Valorphin In Vitro and In Vivo: Combined Action with Cytostatic Drugs

  Elena Yu. Blishchenko, Olga V. Sazonova, Olga A. Kalinina, Ekaterina V. Moiseeva, Arpad A. Vass, Andrey A. Karelin, Vadim T. Ivanov
  Pages 117 - 123

Profiles in Science

• Was Warburg Right? Or Was It That Simple?

  Britton Chance
  Pages 124 - 125

Book Review

• Marksmanship Elusive in Targeted Drug Delivery

  Edwin P. Rock
  Pages 126 - 127