Table of Contents

Volume 1, Issue 5

  September/October 2002

  Pages 445 - 590

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Editor's Corner

• Cover Image

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• Letter to the Editorial Board

  Wafik S. El-Deiry
  Page 445

• In This Issue

  Karl Münger
  Pages 446 - 447

Reviews

• Tumor Microenvironment and the Response to Anticancer Therapy

  J. Martin Brown
  Pages 448 - 453

• Cellular Adhesion Pathways and Metastatic Potential of Human Melanoma

  Eric C. McGary, Dina Chelouche Lev and Menashe Bar-Eli
  Pages 454 - 459

• Notch Signaling in Cancer

  Eric J. Allenspach, Ivan Maillard, Jon C. Aster and Warren S. Pear
  Page 460

• DNA Repair and Tumorigenesis: Lessons from Hereditary Cancer Syndromes

  Christopher D. Heinen, Christoph Schmutte and Richard Fishel
  Page 461

• Flt-3 Ligand: A Potent Dendritic Cell Stimulator and Novel Antitumor

  Jian Dong, Christopher M. McPherson and Peter J. Stambrook
  Pages 462 - 465

Exegesis

• Transactivation of Repair Genes by BRCA1

  Wafik S. El-Deiry
  Pages 466 - 467

Research Papers

• c-Myc Overcomes Cell Cycle Inhibition by CBFβ-SMMHC

  Florence Bernardin, Yandan Yang, Cur I. Civin and Alan D. Friedman
  Pages 468 - 472

• A Naturally Occurring Allele of BRCA1 Coding for a Temperature-Sensitive Mutant Protein

  Terri Worley, Johan Vallon-Christersson, Blase Billack, Åke Borg and Alvaro A. Monteiro
  Pages 473 - 477

• Mutations in the BRCT Domain Confer Temperature Sensitivity to BRCA1 in Transcription Activation

  Marcelo A. Carvalho, Blase Billack, Emily Chan, Terri Worley, Charmagne Cayanan and Alvaro A. Monteiro
  Pages 478 - 484

Commentary

• Creating a Tool-Kit for Exploring BRCA1 Fnction

  Jeffrey D. Parvin
  Pages 485 - 486

Research Paper

• p53 Null Mutations are Associated with a Telomerase Negative Phenotype in Ovarian Carcinoma

  Anil K. Sood, Jeremy Coffin, Sarvenaz Jabbari, Richard E. Buller, Mary J.C. Hendrix and Al Klingelhutz
  Pages 487 - 493

Commentary

• p53—A Key Player in the Telomere Dynamics

  Mihaela Velicescu and Louis Dubeau
  Pages 494 - 500

Research Paper

• Doxorubicin Pretreatment Sensitizes Prostate Cancer Cell Lines to TRAIL Induced Apoptosis Which Correlates with the Loss of c-FLIP Expression

  Margaret M. Kelly, Brian D. Hoel and Christina Voelkel-Johnson
  Pages 501 - 508

Commentary

• The FLIP Variation on the TRAIL DISC: Doxorubicin Conducts the Swan Song

  Fei Guo and Kapil Bhalla
  Pages 509 - 510

Research Paper

• Mismatch Repair Gene Mutations in Renal Cell Carcinoma

  Fredrick S. Leach, Moon Koh, Kirti Sharma, Glenn McWilliams, LaTonia Talifero-Smith, Amanda Codd, Raul Olea and Ossama Elbahloul
  Pages 511 - 517

Commentary

• Renal Cell Carcinoma: Taking Care of Business

  Patrice J. Morin
  Pages 518 - 519

Research Paper

• Didox (A Novel Ribonucleotide Reductase Inhibitor) Overcomes bcl-2 Mediated Radiation Resistance in Prostate Cancer Cell Line PC-3

  Mohammed S. Inayat, Damodaran Chendil, Mohammed Mohiuddin, Howard L. Elford, Vincent S. Gallicchio and Mansoor M. Ahmed
  Pages 520 - 526

Commentary

• Ribonucleotide Reductase Inhibition: Regulation of the Radiosensitive Phenotype via NFkB and Bcl-2

  Paul Dent
  Pages 527 - 528

Research Paper

• Gene Therapy of Prostate Cancer with the Soluble Vascular Endothelial Growth Factor Receptor Fk1

  Christian M. Becker, Filip A. Franebo, Irina Iordanescu, Danielle J. Behonick, Mei-Chiung Shih, Patricia Dunning, Richard C. Mulligan, George A. Taylor and Bruce R. Zetter
  Pages 529 - 534

Commentary

• Modeling Antiangiogenesis Gene Therapy

  Jeff H. Tsai and William M.F. Lee
  Pages 535 - 536

Research Paper

• IL-10/IL-10 Receptor Signaling Regulates TIMP-1 Expression

  Min Wang, Youji Hu, Ischiro Shima and Mark E. Stearns
  Pages 537 - 544

Research Philosophy

• Understanding the Cancer Biology Universe: Enigmas, Context and Future Prospects

  Donald S. Coffey
  Pages 545 - 548

• Philosophical Views: The Changing Complexion of America's Academic Research Enterprise

  Mary J.C. Hendrix
  Pages 549 - 551

• Whose Hypothesis? Ciphering, Sectorials, D Lesions, Freckles and the Operation of Stigler's Law

  Scott E. Kern
  Pages 552 - 562

Meeting Reports

• Shifting Paradigms in Tumor Metastasis: Challenges and Opportunities—A Workshop Report

  J. Thomas Parsons, Bruce Zetter and Suresh Mohla
  Pages 563 - 566

Book Review

• The Class II Tumor Suppressor Masping: From Bench to Bedside

  Vimla Band
  Pages 567 - 568