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Table of Contents

April 2007

volume 6| issue 4



Editor's Corner

Cover Image


Volume: 6 | Issue: 4

Open Access Article


Antero G. So, M.D., Ph.D., 1932–2007


Volume: 6 | Issue: 4

Open Access Article



News

Insights Into the Origins of Breast Cancer and Its Putative Stem Cells


Volume: 6 | Issue: 4 | Page 477

Open Access Article


Transglutaminase as a Mediator of Drug Resistance


Volume: 6 | Issue: 4 | Pages: 477 - 478

Open Access Article


Biomarkers May Predict Propensity for Angiogenesis in Ovarian Cancer


Volume: 6 | Issue: 4 | Pages: 478 - 479

Open Access Article


Splice Variant of a Growth Factor Receptor Promotes Ligand-Independent Growth


Volume: 6 | Issue: 4 | Page 479

Open Access Article


Timeless/Tipin Complex Protects From UV Damage


Volume: 6 | Issue: 4 | Page 480

Open Access Article



Review

MUC1: A Target Molecule for Cancer Therapy

Ravibhushan Singh and Dilip Bandyopadhyay
Volume: 6 | Issue: 4 | Pages: 481 - 486

Open Access Article



Journal Club

Hsp60 and Hsp10 as Antitumour Molecular Agents

Francesco Cappello, Anna M. Czarnecka, Giampiero La Rocca, Antonino Di Stefano, Giovanni Zummo and Alberto J. L. Macario
Volume: 6 | Issue: 4 | Pages: 487 - 489

Open Access Article



Clinical Trials

A Phase II Study of Ixabepilone (BMS-247550) in Metastatic Renal-Cell Carcinoma

Edwin M. Posadas, Samir Undevia, Elizabeth Manchen, James L. Wade, Dimitrios Colevas, Theodore Karrison, Everett E. Vokes and Walter M. Stadler
Volume: 6 | Issue: 4 | Pages: 490 - 493

Open Access Article



Research Paper

Profiling of Selenomethionine Responsive Genes in Colon Cancer by Microarray Analysis

Anne-Christine Goulet, George Watts, Jean L. Lord and Mark A Nelson
Volume: 6 | Issue: 4 | Pages: 494 - 503

Open Access Article


Pheophorbide a, an Active Component in Scutellaria barbata, Reverses P-glycoprotein-mediated Multidrug Resistance on a Human Hepatoma Cell Line R-HepG2

Patrick Ming-Kuen Tang, Judy Yuet-Wa Chan, Dong-Mei Zhang, Shannon Wing-Ngor Au, Wing-Ping Fong, Siu-Kai Kong, Stephen Kwok-Wing Tsui, Mary Mui-Yee Waye, Thomas Chung-Wai Mak and Kowk-Pui Fung
Volume: 6 | Issue: 4 | Pages: 504 - 509

Open Access Article


Mechanistic Analysis and Comparison of Viral Fusogenic Membrane Proteins for their Synergistic Effects on Chemotherapy

Dennis Hoffmann, Thomas Grunwald, Seraphin Kuate and Oliver Wildner
Volume: 6 | Issue: 4 | Pages: 510 - 518

Open Access Article


LS14 Cells: A Model for Chemoresistance in Liposarcoma

Elizabeth W. LaPensee, Shamantha P. Reddy, Eric R. Hugo, Sandy J. Schwemberger and Nira Ben-Jonathan
Volume: 6 | Issue: 4 | Pages: 519 - 524

Open Access Article


High Copy Amplification of the Aurora-A Gene is Associated with Chromosomal Instability Phenotype in Human Colorectal Cancers

Naoshi Nishida, Takeshi Nagasaka, Kazuhiro Kashiwagi, Richard Boland and Ajay Goel
Volume: 6 | Issue: 4 | Pages: 525 - 533

Open Access Article


IGFBP-3 Regulates Esophageal Tumor Growth Through IGF-Dependent and Independent Mechanisms

Munenori Takaoka, Seok-Hyun Kim, Takaomi Okawa, Carmen Michaylira, Doug Stairs, Cameron Johnston, Claudia D. Andl, Ben Rhoades, James Lee, Andres Klein-Szanto, Wafik S. El-Deiry and Hiroshi Nakagawa
Volume: 6 | Issue: 4 | Pages: 534 - 540

Open Access Article


Velafermin Improves Gastrointestinal Mucositis Following Irinotecan Treatment in Tumor-Bearing DA Rats

Rachel J Gibson, Andrea M Stringer, Joanne M Bowen, Richard M Logan, Ann S-J Yeoh, Jaimi Burns, Enrique Alvarez and Dorothy M K Keefe
Volume: 6 | Issue: 4 | Pages: 541 - 547

Open Access Article


ErbB3 Expression and Dimerization with EGFR Influence Pancreatic Cancer Cell Sensitivity to Erlotinib

Andrey Frolov, Kyle Schuller, Ching-Wei D. Tzeng, Emily E. Cannon, Brandon C. Ku, J. Harrison Howard, Selwyn M. Vickers, Martin J. Heslin, Donald J. Buchsbaum and J. Pablo Arnoletti
Volume: 6 | Issue: 4 | Pages: 548 - 554

Open Access Article


Using Attenuated Salmonella Typhi as Tumor Targeting Vector for MDR1 siRNA Delivery: An Experimental Study

Zhongming Jiang, Ping Zhao, Zhonghua Zhou, Jun Liu, Liying Qin and Hongwei Wang
Volume: 6 | Issue: 4 | Pages: 555 - 560

Open Access Article


Epidermal Growth Factor Receptor Plays a Significant Role in Hepatocyte Growth Factor Mediated Biological Responses in Mammary Epithelial Cells

Alyssa R. Bonine-Summers, Mary E. Aakre, Kimberly A. Brown, Carlos L. Arteaga, Jennifer A. Pietenpol, Harold L. Moses and Nikki Cheng
Volume: 6 | Issue: 4 | Pages: 561 - 570

Open Access Article


EGFR Inhibition in Glioblastoma Cells Induces G2/M Arrest and is Independent of p53

Gurpreet S. Kapoor, Antoire Christie and Donald M. O’Rourke
Volume: 6 | Issue: 4 | Pages: 571 - 579

Open Access Article


Therapeutic Effect of Arsenic Trioxide (As2O3) on Cervical Cancer In Vitro and In Vivo through Apoptosis Induction

Jing Yu, Haili Qian, Yunfeng Li, Yang Wang, Xueyan Zhang, Xiao Liang, Ming Fu and Chen Lin
Volume: 6 | Issue: 4 | Pages: 580 - 586

Open Access Article


Silencing of Heparanase by siRNA Inhibits Tumor Metastasis and Angiogenesis of Human Breast Cancer In Vitro and In Vivo

Zhong-Hua Zhang, Yi Chen, Hua-Jun Zhao, Cheng-Ying Xie, Jian Ding and Yong-Tai Hou
Volume: 6 | Issue: 4 | Pages: 587 - 595

Open Access Article


Evidence for the Involvement of Purα in Response to DNA Replication Stress

Huichen Wang, Meijuan Wang, Krzysztof Reiss, Nune Darbinian-Sarkissian, Edward M. Johnson, George Iliakis, Shohreh Amini, Kamel Khalili and Jay Rappaport
Volume: 6 | Issue: 4 | Pages: 596 - 602

Open Access Article


Proteasome InhibitIon Specifically Sensitizes Leukemic Cells to Anthracyclin-Induced Apoptosis Through the Accumulation of Bim and Bax Pro-Apoptotic Proteins

A. Pigneux, F.X. Mahon, F. Moreau-Gaudry, M. Uhalde, H. de Verneuil, F. Lacombe, J. Reiffers, N. Milpied, V. Praloran and F. Belloc
Volume: 6 | Issue: 4 | Pages: 603 - 611

Open Access Article


Phenoxodiol-Topotecan Co-Administration Exhibit Significant Anti-Tumor Activity Without Major Adverse Side Effects

Ayesha B. Alvero, David Brown, Michele Montagna, Marissa Matthews and Gil Mor
Volume: 6 | Issue: 4 | Pages: 612 - 617

Open Access Article



Commentary

Heterogeneity of Stromal Fibroblasts in Tumor

Akiro Orimo and Robert A. Weinberg
Volume: 6 | Issue: 4 | Pages: 618 - 619

Open Access Article



Profiles and Legacies

Finding the Interface: More than an Image

Yves Pommier
Volume: 6 | Issue: 4 | Pages: 620 - 623

Open Access Article