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Table of Contents

February 2007

volume 6| issue 2



Editor's Corner

Cover Image


Volume: 6 | Issue: 2

Open Access Article


In Memory of Russell Klein, Ph.D.; 1962-2006


Volume: 6 | Issue: 2 | Page 131

Open Access Article



News

FOXO Genes act in vivo as Tumor Suppressors


Volume: 6 | Issue: 2 | Pages: 132 - 133

Open Access Article


Lovastatin and Cyclopamine combination in Medulloblastoma


Volume: 6 | Issue: 2 | Page 133

Open Access Article


Anti-tumor Effect of Nanoparticles that Target Blood Clotting in Tumor Vasculature


Volume: 6 | Issue: 2 | Pages: 133 - 134

Open Access Article


p53 and FUS1 in Nanoparticles show Anti-tumor Efficacy in Preclinical Study


Volume: 6 | Issue: 2 | Pages: 134 - 135

Open Access Article


NEDD4-1 Regulates PTEN Stability and Localization


Volume: 6 | Issue: 2 | Page 135

Open Access Article


Genetic Fingerprints Identify Brain Tumors' Origins


Volume: 6 | Issue: 2 | Pages: 135 - 136

Open Access Article


Clues to Pancreatic Cancer Stem Cells


Volume: 6 | Issue: 2 | Pages: 136 - 137

Open Access Article


Gemcitabine plus Bevacizumab no better than Gemcitabine alone in Clinical Study of 600 Patients with Pancreatic Cancer


Volume: 6 | Issue: 2 | Page 137

Open Access Article


Her2 and Estrogen Activate Src and Inactivate p27 in Breast Cancer


Volume: 6 | Issue: 2 | Page 138

Open Access Article


Gregory Enders Joins Fox Chase Cancer Center


Volume: 6 | Issue: 2 | Pages: 138 - 139

Open Access Article


Cancer Biologist Steven B. McMahon, Ph.D., Joins Kimmel Cancer Center at Jefferson


Volume: 6 | Issue: 2 | Page 139

Open Access Article


Raymond DuBois Named Executive Vice President and Provost at MD Anderson Cancer Center


Volume: 6 | Issue: 2 | Pages: 139 - 140

Open Access Article



Journal Club

Why Do Tumors Metastasize?

Miguel López-Lázaro
Volume: 6 | Issue: 2 | Pages: 141 - 144

Open Access Article



Clinical Trials

Active Immunotherapy with 1E10 Anti-Idiotype Vaccine in Patients with Small Cell Lung Cancer. Report of a Phase I Trial

E. Neninger, R.M. Diaz, A. de la Torre, G. Saurez, M.R. Gabri, D.S. Alonso, B. Wilkinson, A.M. Alfonso, T. Combet, Rodríguez R. Perez and A.M. Vázquez
Volume: 6 | Issue: 2 | Pages: 145 - 150

Open Access Article



Commentary

Come Forth 1E10 Anti-Idiotype Vaccine: Delivering the Promise to Immunotherapy of Small Cell Lung Cancer

Masoud H. Manjili
Volume: 6 | Issue: 2 | Pages: 151 - 152

Open Access Article



Brief Communication

Metastatic Cancer Cells from c-erbB-2 Negative Primary Breast Cancer Maintain the Original c-erbB-2/HIF1α Phenotype

Alexandra Giatromanolaki, Michael I. Koukourakis, Costantinos Simopoulos and Efthimios Sivridis
Volume: 6 | Issue: 2 | Pages: 153 - 155

Open Access Article



Research Paper

Bortezomib Sensitizes Human Head and Neck Carcinoma Cells SQ20B to Radiation

Charles N. Weber, George J. Cerniglia, Amit Maity and Anjali K. Gupta
Volume: 6 | Issue: 2 | Pages: 156 - 159

Open Access Article


Lack of p53 Augments Thymoquinone-Induced Apoptosis and Caspase Activation in Human Osteosarcoma Cells

Martin Roepke, Antje Diestel, Khouloud Bajbouj, Diana Walluscheck, Peter Schonfeld, Albert Roessner, Regine Schneider-Stock and Hala Gali-Muhtasib
Volume: 6 | Issue: 2 | Pages: 160 - 169

Open Access Article


Effects of Etoposide and Cyclophosphamide Acute Chemotherapy on Growth Plate and Metaphyseal Bone in Rats

Cory J. Xian, Johanna C. Cool, Jeffery van Gangelen, Bruce K. Foster and Gordon S. Howarth
Volume: 6 | Issue: 2 | Pages: 170 - 177

Open Access Article


Curcumin Induces G2/M Arrest and Apoptosis in Cisplatin-Resistant Human Ovarian Cancer Cells by Modulating Akt and p38 MAPK

Nathan M. Weir, Karuppaiyah Selvendiran, Vijay Kumar Kutala, Liyue Tong, Shilpa Vishwanath, Murugesan Rajaram, Susheela Tridandapani, Shrikant Anant and Periannan Kuppusamy
Volume: 6 | Issue: 2 | Pages: 178 - 184

Open Access Article


Valproic Acid Induces Apoptosis, p16INK4A Upregulation and Sensitization to Chemotherapy in Human Melanoma Cells

Alessandra Valentini, Paolo Gravina, Giorgio Federici and Sergio Bernardini
Volume: 6 | Issue: 2 | Pages: 185 - 191

Open Access Article


Bin1 Attenuation in Breast Cancer is Correlated to Nodal Metastasis and Reduced Survival

Arezoo Ghaneie, Vlasta Zemba-Palca, Hiromichi Itoh, Kaori Itoh, Daitoku Sakamuro, Seigo Nakamura, Alejandro Peralta Soler and George C. Prendergast
Volume: 6 | Issue: 2 | Pages: 190 - 194

Open Access Article


Combining an mTOR Antagonist and Receptor Tyrosine Kinase Inhibitors for the Treatment of Prostate Cancer

David Masiello, M. Golam Mohi, Nicole C. McKnight, Bradley Smith, Ben G. Neel, Stevan P. Balk and Glenn J. Bubley
Volume: 6 | Issue: 2 | Pages: 195 - 201

Open Access Article


Selectively Oncolytic Mutant of HSV-1 Lyses HeLa Cells Mediated by Ras/RTN3

Yue Su, Huabin Zhu, Wei Xiao, Qin Xu, Lei Zhu, Xianrong Zhang, Qinwen Wan, Shumin Zhou, Enqi Du, Hua Xu, Lunguang Yao, Songya Lv, Baoli Hu, Yingle Liu and Yipeng Qi
Volume: 6 | Issue: 2 | Pages: 202 - 208

Open Access Article


Analysis of Apoptosome Dysregulation in Pancreatic Cancer and of its Role in Chemoresistance

Marco Corvaro, Claudia Fuoco, Martin Wagner and Francesco Cecconi
Volume: 6 | Issue: 2 | Pages: 209 - 217

Open Access Article


Expression of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN/CD147) in Pancreatic Neoplasm and Pancreatic Stellate Cells

Weiwei Zhang, Mert Erkan, Ivane Abiatari, Nathalia A. Giese, Klaus Felix, Hany Kayed, Markus W. Buchler and Jörg Kleeff
Volume: 6 | Issue: 2 | Pages: 218 - 227

Open Access Article


Zyflamend®-Mediated Inhibition of Human Prostate Cancer PC3 Cell Proliferation: Effects on 12-LOX and Rb Protein Phosphorylation

Peiying Yang, Carrie Cartwright, Diana Chan, Mary Vijjeswarapu, Jibin Ding and Robert A. Newman
Volume: 6 | Issue: 2 | Pages: 228 - 236

Open Access Article



Commentary

Inhibition of Lipoxygenase Activity: Implications for the Treatment and Chemoprevention of Prostate Cancer

Mark A Nelson
Volume: 6 | Issue: 2 | Page 237

Open Access Article



Research Paper

Forced Expression of RDH10 Gene Retards Growth of HepG2 Cells

Elena Rossi, Paolo Picozzi, Beatrice Bodega, Cristiana Lavazza, Carmelo Carlo-Stella, Anna Marozzi and Enrico Ginelli
Volume: 6 | Issue: 2 | Pages: 238 - 245

Open Access Article


Bcl2/bcl-xl Inhibitor Engenders Apoptosis and Increases Chemo-sensitivity In Mesothelioma

Xiaobo Cao, Charles Rodarts, Lidong Zhang, Clinton D. Morgan, James Littlejohn and W. Roy Smythe
Volume: 6 | Issue: 2 | Pages: 246 - 252

Open Access Article


Dose-Dependent Reduction of Dietary Protein-Induced Colonocyte DNA Damage by Resistant Starch in Rats Correlates More Highly with Caecal Butyrate than with Other Short Chain Fatty Acids

Shusuke Toden, Anthony R. Bird, David L. Topping and Michael A. Conlon
Volume: 6 | Issue: 2 | Pages: 253 - 258

Open Access Article



Commentary

Fermentation of Starch and Protein in the Colon: Implications for Genomic Instability

Richard K. Le Leu and Graeme P. Young
Volume: 6 | Issue: 2 | Pages: 259 - 260

Open Access Article



Research Paper

Oridonin Induced Apoptosis Through Akt and MAPKs Signaling Pathways in Human Osteosarcoma Cells

Song Jin, Jing-nan Shen, Jin Wang, Gang Huang and Jia-Guo Zhou
Volume: 6 | Issue: 2 | Pages: 261 - 268

Open Access Article


Effect of Celecoxib on E-cadherin, VEGF, Microvessel Density and Apoptosis in Gastric Cancer

Yongning Zhou, Juntao Ran, Chenwei Tang, Jing Wu, Li Honghua, Li Xingwen, Cheng Ning and Liang Qiao
Volume: 6 | Issue: 2 | Pages: 269 - 275

Open Access Article



Commentary

First Steps Towards Molecular Prevention in Gastric Carcinogenesis

Matthias P.A. Ebert and Christoph Röcken
Volume: 6 | Issue: 2 | Pages: 276 - 277

Open Access Article



Research Paper

Clinical and Mechanistic Aspects of Glucocorticoid-Induced Chemotherapy Resistance in the Majority of Solid Tumors

Chengwen Zhang, Till Wenger, Jürgen Mattern, Septimia Ilea, Christian Frey, Paul Gutwein, Peter Altevogt, Wolfram Bodenmüller, Nikolaus Gassler, Philipp A, Schnabel, Hendrik Dienemann, Alexander Marmé, Markus Hohenfellner, Axel Haferkamp, Jesco Pfitzenmaier, Hermann-Josef Gröne, Armin Kolb, Peter Büchler, Markus Büchler, Helmut Friess, Werner Rittgen, Lutz Edler, Klaus-Michael Debatin, Peter H. Krammer, Hans P. Rutz and Ingrid Herr
Volume: 6 | Issue: 2 | Pages: 278 - 287

Open Access Article



Commentary

Loss of p53 and Overexpression of EphA2 Predict Poor Prognosis for Ovarian Cancer Patients

Linda Meade-Tollin and Jesse D. Martinez
Volume: 6 | Issue: 2 | Pages: 288 - 289

Open Access Article


How Do Changes In Tumor Matrix Affect the Outcome of Virotherapy?

Jin Cheng, Harald Sauthoff and John G. Hay
Volume: 6 | Issue: 2 | Pages: 290 - 292

Open Access Article


Pancreatic Cancer Inhibition by Specific Knockdown of K-ras Mutant Allele Expression

Eric J. Bernhard
Volume: 6 | Issue: 2 | Pages: 293 - 294

Open Access Article



Profiles and Legacies

Serendipity and Chance in One’s Life and Scientific Career

John B. Little
Volume: 6 | Issue: 2 | Pages: 295 - 300

Open Access Article