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Table of Contents

jan 2004

volume 3| issue 1



Editor's Corner

Cover Image

NA
Volume: 3 | Issue: 1 | Pages: nA

Open Access Article


Letter to the Editorial Board

Wafik S. El-Deiry, Editor-in-Chief
Volume: 3 | Issue: 1 | Page 3

Open Access Article



Review

Progress in the Development of Nucleic Acids Therapeutics for Cancer

Anna Kalota, Susan E. Shetzline and Alan Gewirtz
Volume: 3 | Issue: 1 | Pages: 4 - 12

Open Access Article


Leukemic Transformation

Ying-Wei Lin and Peter D. Aplan
Volume: 3 | Issue: 1 | Pages: 13 - 20

Open Access Article


Getting Back on Track, or what to do when apoptosis is de-railed: Recoupling Oncogenes to the Apoptotic Machinery

Howard Fearnhead
Volume: 3 | Issue: 1 | Pages: 21 - 28

Open Access Article


Hypoxia, Oxygen Sensor and Carcinogenic Metals

Patrick Maxwell and Konstantin Salnikow
Volume: 3 | Issue: 1 | Pages: 29 - 35

Open Access Article


Wnt Signaling and Breast Cancer

Louise R. Howe and Anthony M.C. Brown
Volume: 3 | Issue: 1 | Pages: 36 - 41

Open Access Article



Journal Club

Histone 1.2, Another Housekeeping Protein that Kills

Wei-xing Zong
Volume: 3 | Issue: 1 | Pages: 42 - 43

Open Access Article


Cytochrome c: A Crosslink between the Mitochondria and the Endoplasmic Reticulum in Ca2+-Dependent Apoptosis

Shulin Wang and Wafik S. El-Deiry
Volume: 3 | Issue: 1 | Pages: 44 - 46

Open Access Article



Research Paper

Fibronectin Alters Cell Survival and Intracellular Signaling of Confluent A549 Cultures After Irradiation

N. Cordes and C. Beinke
Volume: 3 | Issue: 1 | Pages: 47 - 53

Open Access Article



Commentary

A New Twist to Radiation Sensitivity: Extracellular Matrix Composition Modulates Cell Cycle Checkpoint Control

Ulrich Rodeck
Volume: 3 | Issue: 1 | Page 54

Open Access Article



Research Paper

Differential Effects of Selective COX-2 Inhibitors on Cell Cycle Regulation and Proliferation of Glioblastoma Cell Lines

Adel Kardosh, Martina Blumenthal, Wei Jun Wang, Thomas C. Chen and Axel H. Schönthal
Volume: 3 | Issue: 1 | Pages: 55 - 62

Open Access Article



Commentary

Glioma Growth Inhibition by Selectcive COX-2 Inhibitors via Clyclooxygenase Indepdent Pathways: Implications for Therapy

Durga P. Cherukuri and Mark A. Nelson
Volume: 3 | Issue: 1 | Pages: 63 - 64

Open Access Article



Research Paper

Suppression of Epithelial Cell Transformation and Induction of Actin Dependent Differentiation by Dominant Negative Rac1, but not Ras, Rho or Cdc42

Margaret P. Quinlan
Volume: 3 | Issue: 1 | Pages: 65 - 70

Open Access Article



Commentary

Rac Transformation: The Actin Connection

Michael Olson
Volume: 3 | Issue: 1 | Pages: 71 - 72

Open Access Article



Research Paper

Evaluation of Microsatellite Instability, hMLH1 Expression and hMLH1 Promoter Hypermethylation in Defining the MSI Phenotype of Colorectal Cancer

Christian N. Arnold, Ajay Goel, Carolyn Compton, Victoria Marcus, Donna Niedzwiecki, Jeannette M. Dowell, Linda Wasserman, Toru Inoue, Robert J. Mayer, Monica M Bertagnolli and C. Richard Boland
Volume: 3 | Issue: 1 | Pages: 73 - 78

Open Access Article



Commentary

Defining the Microsatellite Instability Phenotype in Colorectal Cancer Through Analysis of Surrogate Markers

Eric R. Fearon
Volume: 3 | Issue: 1 | Pages: 79 - 81

Open Access Article



Research Paper

Methylation and Regulation of Expression of Different Retinoic Acid Receptor Beta Isoforms in Human Colon Cancer

Emile M. Youssef, Marcos R.H. Estecio and Jean-Pierre J. Issa
Volume: 3 | Issue: 1 | Pages: 82 - 86

Open Access Article



Commentary

Retinoic Acid Receptor Beta and Colon Cancer

Shi-Yong Sun
Volume: 3 | Issue: 1 | Pages: 87 - 88

Open Access Article



Research Paper

A Phase II Study of Topotecan and Cyclophosphamide with G-CSF in Patients with Small Cell Lung Cancer with Poor Prognostic Factors

Erole M. Hobdy, Eric Kraut, Gregory Masters, Kathleen Blum, Anne McKeon,Boyd Byrd and John R. Murren
Volume: 3 | Issue: 1 | Pages: 89 - 93

Open Access Article



Commentary

Topotecan in Small Cell Lung Cancer: First or Second Line?

Barbara G. Campling
Volume: 3 | Issue: 1 | Pages: 94 - 95

Open Access Article



Research Paper

The Tyr-Kinase Inhibitor AG879, that Blocks the ETK-PAK1 Interaction, Suppresses the RAS-induced PAK1 Activation and Malignant Transformation

Hong He, Yumiko Hirokawa, Aviv Gazit , Yoshihiro Yamashita, Hiroyuki Mano, Yuko Kawakami, Toshiaki Kawakami, Ching-Yi Hsieh, Hsing-Jien Kung, Guillaume Lessene, Jonathan Baell, Alexander Levitzki and Hiroshi Maruta
Volume: 3 | Issue: 1 | Pages: 96 - 101

Open Access Article



Commentary

Targeting PAK etk…

Guo-Lei Zhou and Jeffrey M. Field
Volume: 3 | Issue: 1 | Pages: 102 - 103

Open Access Article



Research Paper

SAGE Identification and Fluorescence Imaging Analysis of Genes and Transcripts in Melanomas and Precursor Lesions

Amanda Pfaff Smith, Ashani T. Weeraratna, Justin R. Spears, Paul S. Meltzer and Dorothea Becker
Volume: 3 | Issue: 1 | Pages: 104 - 109

Open Access Article


Expression Analysis of Genes identified by Molecular Profiling of VGP Melanomas and MGP Melanoma-Positive Lymph Nodes

Shannon L. McDonald, Howard D. Edington, John M. Kirkwood and Dorothea Becker
Volume: 3 | Issue: 1 | Pages: 110 - 120

Open Access Article



Commentary

Gene Expression Profiling Of Human Cutaneous Melanoma: Are We There Yet?

Jeffrey E. Gershenwald and Menashe Bar-Eli
Volume: 3 | Issue: 1 | Pages: 121 - 123

Open Access Article


Reassessing the Usual Suspects Causing a Commotion in the Blood (and Vessels?)

Jedd Wolchok and Jan Vilcek
Volume: 3 | Issue: 1 | Pages: 124 - 125

Open Access Article



Profiles in Science

Genetic Systems for the Diagnosis and Treatment of Human Disease

Albert Deisseroth
Volume: 3 | Issue: 1 | Pages: 126 - 132

Open Access Article



Book Review

Culturing Human Cancer Cells

Ravi Amaravadi
Volume: 3 | Issue: 1 | Pages: 133 - 134

Open Access Article