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Editor's Corner

Cover Image

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This issue of Cancer Biology & Therapy features a "Focused Review Series" commemorating the 10th anniversary of the discovery of the breast cancer suppressor gene BRCA1. Included are reviews by prominent members of the scientific community working on breast cancer and BRCA1. The cover image (provided by Ralph Scully) depicts immunofluorescent staining of BRCA1 protein (green) and DAPI staining of nuclear chromatin (blue) where nuclear dots are evident in the human osteosarcoma cell line, U2OS. Top inset: Crystal Structure (provided by Nebojsa Mirkovic) of the BRCT domains of BRCA1 (Williams el al. Nature Structural Biology 8:838-842, 2001) with missense mutations. Middle inset: Whole mount of mouse mammary gland (provided by Chuxia Deng) showing small initiating tumor lesion in Brca1 conditional mutant mice. Bottom inset: NMR structure (provided by Rachel Klevit) of the BRCA1 RING domain.