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Journal Club
Zebrafish: Swimming Towards a Role for Fanconi Genes in DNA Repair
Kimberly A. Scata and Wafik S. El-Deiry
volume 3 | issue 6
june 2004Pages: 501-502
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The zebrafish, Danio rerio, has become a favorite model organism for geneticists and developmental biologists. Recently cancer biologists have turned to this tiny fish to help them unravel the mysteries of conserved pathways such as the Fanconi Anemia (FA) pathway. Although a relatively rare disease, the genes involved in FA are part of a large network of DNA damage response/repair genes. Liu and colleagues have recapitulated some of the clinical manifestations of human FA by knocking out the zebrafish FANCD2 gene thereby providing a new model for probing the underlying causes of these phenotypes.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.