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Research Paper

Therapeutic potential of various β-glucan sources in conjunction with anti-tumor monoclonal antibody in cancer therapy

Michael Driscoll, Richard Hansen, Chuanlin Ding, Daniel E. Cramer and Jun Yan

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Combined β-glucan with anti-tumor mAb therapy has demonstrated therapeutic efficacy in murine tumor models. The current study was designed to compare the therapeutic efficacy of various sources of β-glucans. Our studies demonstrated that yeast β-glucan, in combination with anti-tumor mAb, resulted in significantly smaller tumor burdens and achieved enhanced long-term survival compared to mAb alone or β-glucan extracts from mushrooms. Further studies indicated that yeast β-glucan particle was superior to mushroom extracts in inducing cytokine secretion, particularly IL-12 production in dendritic cells (DCs). In addition, results showed that cytokine production was markedly decreased in MyD88-deficient macrophages and DCs but not in complement receptor 3 (CR3)-deficient mice. Our data suggest that yeast β-glucan demonstrates much stronger adjuvant activity compared to mushroom β-glucan extracts in tumor therapy. This effect of yeast β-glucan may be in part ascribed to the cytokine secretion by DCs and macrophages and bioavailability of active β-glucan moiety.

Authors

Michael Driscoll

Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY

Richard Hansen

Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY

Chuanlin Ding

Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY

Daniel E. Cramer

Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY

Jun Yan

Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.