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Journal Club
Temporal-mediated FGFR1 independence: Implications for targeting candidate molecules in prostate cancer
Robert J. Miles , Douglas K. Price and William D. Figg
volume 7 | issue 8
August 2008Pages: 1180 - 1181
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In a recent study, Winter et al. assessed the effects of Fibroblast Growth Factor Receptor 1 (FGFR1) expression on the angiogenic switch, while Acevedo et al. investigated whether FGFR1 occupies a causative role in prostate cancer initiation. The former report found that FGFR1 is sufficient to induce angiogenesis, and the latter that FGFR1 activation can help trigger prostate cancer progression. By virtue of utilizing the conditional JOCK-1 model, both groups identified FGFR1-independent stages during onset of angiogenesis and adenocarcinoma, respectively. These findings highlight the need to consider both the temporal and spatial molecular mechanisms contributing to prostate cancer, which may have profound impacts on therapeutic targeting.
Authors
Robert J. Miles
Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
Douglas K. Price
Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
William D. Figg
Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.