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Research Paper
Molecular basis of pathogenesis, prognosis and therapy in chronic lymphocytic leukaemia
Jiezhong Chen and Nigel A.J. McMillan
volume 7 | issue 2
February 2008Pages: 174 - 179
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B-cell chronic lymphocytic leukemia (CLL) is caused by the abnormal accumulation of non-functional B-cells in peripheral blood and bone marrow. However, the precise aetiology and mechanism of the disease are unclear. Recently, progress has been made in the identification of both the genetic deficiencies and environmental factors that may underlie CLL. This has provided some clues to the nature of the disease, but no definitive cures. Although treatment has increased remission time, at present the disease is not curable by conventional therapy. Further studies of the pathogenesis of CLL are needed, as are the development of suitable cell lines and animal models in which to study it. This review summarises the most recent progress in CLL with emphasis on molecular events and possible implications in therapy.
Authors
Jiezhong Chen
University of Queensland, Brisbane, Australia
Nigel A.J. McMillan
University of Queensland, Brisbane, Australia