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Review
Progress in the Development of Nucleic Acids Therapeutics for Cancer
Anna Kalota, Susan E. Shetzline and Alan Gewirtz
volume 3 | issue 1
jan 2004Pages: 004-012
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Numerous types of cancer are known to have abnormal genes that are of importance in disease states. These genes are attractive targets to approach for treatment of wide range of cancers. In a variety of experimental systems nucleic-acid-based molecules have been shown to be very effective tools for modulating gene expression in a sequence specific manner. Thereby they appear to be one of the most promising cancer therapeutics. They are more specific and low toxic than conventional chemotherapy. However, there are still some obstacles remain to overcome. Many strategies for this purpose are now under development in pre-clinical and clinical research. This article reviews the current directions and novel developments in the field of cancer gene therapy.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.