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Bedside to Bench
Nephron-Sparing Surgery of a Low Grade Renal Cell Carcinoma in a Renal Allograft 12 Years after Transplantation
Thomas M. Mundel, Karl-Ludwig Schaefer, Mario Colombo-Benkmann, Karl-Heinz Dietl, Raihana Diallo-Danebrock and Norbert Senninger
volume 6 | issue 11
November 2007Pages: 1700 - 1703
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Renal cell carcinoma (RCC) occurring in renal allografts after cadaveric kidney transplantation has rarely been observed. RCC accounts for 2.3 % of all malignancies in the general population, but up to 4.8 % of malignancies in renal transplant recipients. Most have been reported in the patient’s own diseased kidneys, whereas RCC in the renal allograft occur in only 10 %. Here, we describe an organ-preserving surgical technique of a malignant renal tumor in a kidney allograft using an harmonic scalpel (Ultracision©) for tumor enucleation. Furthermore we demonstrate by DNA microsatellite analysis the tumor’s genetic origin as donor related. Collectively, we suggest that patients with a well defined low grade RCC in the kidney allograft and altogether low malignancy and good allograft function should only undergo an organ-preserving procedure and short-term postoperative screening.
Authors
Thomas M. Mundel
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
Karl-Ludwig Schaefer
Institute of Pathology; Heinrich-Heine-Universität; Düsseldorf, Germany
Mario Colombo-Benkmann
Westfälische Wilhelms-Universität Münster, Münster, Germany
Karl-Heinz Dietl
Westfälische Wilhelms-Universität Münster, Münster, Germany
Raihana Diallo-Danebrock
Institute of Pathology; Heinrich-Heine-Universität; Düsseldorf, Germany
Norbert Senninger
Westfälische Wilhelms-Universität Münster, Münster, Germany
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.