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Research Paper
Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer
Mozammel H. Gazi, MeiLan He, John C. Cheville and Charles Y.F. Young
volume 7 | issue 1
January 2008Pages: 70 - 75
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By means of protein expression profile, mass spectral and/or RT-PCR analyses we found for the first time IgG Fc binding protein (FcγBP), distinct from Fcγ receptors is expressed in both human and mouse prostates. There is a strong correlation between downregulation of FcγBP and the progression of prostate cancer in Transgenic Adenocarcinoma Mouse Prostate (TRAMP) mice. FcγBP gene expression is significantly reduced or lost in human prostate tumor tissues and prostate cell lines. The differentially expressed FcγBP could reflect its potential role in prostate malignancy as well as an indicator for progression of the cancer.
Authors
Mozammel H. Gazi
Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN
MeiLan He
Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN
John C. Cheville
Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN
Charles Y.F. Young
Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.