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Bedside to Bench
Childhood ALL and Second Neoplasms
Tapan N. Maniar, Inbal Braunstein, Stephen Keefe, Sofia Hussen, Tara Abrams, Angela De Michele and Wafik S. El-Deiry
volume 6 | issue 10
October 2007Pages: 1525 - 1531
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Second malignancies are a significant concern for survivors of childhood acute lymphoblastic leukemia (ALL), in particular patients who have been treated with cranial irradiation. Brain tumors, most commonly meningiomas, are among the most common second neoplasms discovered in these patients. Breast cancer can occur in association with meningioma, but is not thought to be a consequence of treatment for childhood ALL. We describe the molecular genetics and therapy of childhood ALL, the molecular genetics of meningioma, as well as the possible association between meningioma and breast cancer.
Authors
Tapan N. Maniar
Department of Medicine (Hematology/Oncology) and the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA
Inbal Braunstein
Department of Medicine (Hematology/Oncology) and the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA
Stephen Keefe
Department of Medicine (Hematology/Oncology) and the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA
Sofia Hussen
Department of Medicine (Hematology/Oncology) and the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA
Tara Abrams
Department of Medicine (Hematology/Oncology) and the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA
Angela De Michele
Department of Medicine (Hematology/Oncology) and the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA
Wafik S. El-Deiry
University of Pennsylvania School of Medicine
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.