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Wafik S. El-Deiry, M.D., Ph.D.
University of Pennsylvania
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Research Paper
Genetic Variation in 8q24 Associated with Risk of Colorectal Cancer
Stephen B. Gruber, Victor Moreno, Laura S. Rozek, Hedy S. Rennert, Flavio Lejbkowicz, Joseph D. Bonner, Joel K. Greenson, Thomas J. Giordano, Eric R. Fearon and Gad Rennert
Volume 6, Issue 7
July 2007Pages: 1143 - 1147
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Chromosome 8q24 harbors oncogenes known to be involved in pathogenesis of colorectal cancer (CRC) as well as uncharacterized genetic variants that have recently been shown to influence inherited risk of prostate cancer. In a population-based case-control study of colorectal cancer in northern Israel, we investigated the association between variation in 8q24 and risk of CRC. Among 1,861 incident cases and 1,937 population-based controls matched on age, gender, ethnicity, and clinic, rs10505477 was associated with risk of CRC in a dominant model, with an odds ratio = 1.23, 95% confidence interval = 1.05 -1.43, (p=0.008). This association was independently validated in an analysis of cancer among relatives of carriers of the risk allele, with a hazard ratio of 3.2 (95% bootstrap CI = 1.16 – 17.8). Genetic variation at rs10505477 on 8q24 potentially accounts for 14% of CRC in this population and should be replicated in other studies.
Authors
Stephen B. Gruber
Departments of Internal Medicine, Epidemiology, and Human Genetics, University of Michigan Medical School, Ann Arbor, MI
Victor Moreno
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI; Catalan Institute of Oncology (ICO), Barcelona, Spain,
Laura S. Rozek
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI
Hedy S. Rennert
CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center; B. Rappaport Faculty of Medicine, Technion %u2013 Israel Institute of Technology, Haifa, Israel,
Flavio Lejbkowicz
5CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center; B. Rappaport Faculty of Medicine, Technion %u2013 Israel Institute of Technology, Haifa, Israel,
Joseph D. Bonner
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI
Joel K. Greenson
Department of Pathology, University of Michigan, Ann Arbor, MI
Thomas J. Giordano
Department of Pathology, University of Michigan, Ann Arbor, MI
Eric R. Fearon
Departments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI; Department of Pathology, University of Michigan, Ann Arbor, MI
Gad Rennert
5CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center; B. Rappaport Faculty of Medicine, Technion %u2013 Israel Institute of Technology, Haifa, Israel
This is an open-access article
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
