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Journal Club
Hsp60 and Hsp10 as Antitumour Molecular Agents
Francesco Cappello, Anna M. Czarnecka, Giampiero La Rocca, Antonino Di Stefano, Giovanni Zummo and Alberto J. L. Macario
volume 6 | issue 4
April 2007Pages: 487 - 489
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The molecular chaperones Hsp60 and Hsp10 are, according to recent reports, involved in cancer development and progression. We, for instance, have found that their expression varies with distinctive patterns in different malignancies: they are overexpressed in colorectal, exocervical and prostate carcinogenesis, and colorectal cancer progression, but they are downregulated during bronchial carcinogenesis. There is also evidence showing that Hsp60 and Hsp10 can be used as therapeutic agents, for example in rheumatoid arthritis. In view of these findings we want now to call attention to the potential of Hsp60 and Hsp10 in cancer therapy.
Authors
Francesco Cappello
University of Palermo, Palermo, Italy
Anna M. Czarnecka
Medical University of Warsaw, Warszawa, Poland
Giampiero La Rocca
University of Palermo, Palermo, Italy
Antonino Di Stefano
Laboratory of Heart and Lung Cytoimmunopathology, Veruno, Italy
Giovanni Zummo
University of Palermo, Palermo, Italy
Alberto J. L. Macario
University of Maryland Biotechnology Institute, Baltimore, MD, USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.