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Research Paper
IGFBP7 Plays a Potential Tumor Suppressor Role in Colorectal Carcinogenesis
Wenjing Ruan, Enping Xu, Fangying Xu, Yu Ma, Hong Deng, Qiong Huang, Bingjian Lv, Hu Hu, Jie Lin, Jing Cui, Meijuan Di, Jiankang Dong and Maode Lai
volume 6 | issue 3
March 2007Pages: 354 - 359
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Insulin-like growth factor binding protein-7 (IGFBP7) is a gene identified as being low expressed in colorectal adenocarcinoma (CRC) cell lines. In the current study, we investigated the function of IGFBP7 in CRC by transfection studies. We found that IGFBP7 could inhibit cell growth, decrease soft agar colony formation activity and induce apoptosis in RKO and SW620 cells. Correlation analysis between the expression of IGFBP7 in CRC tissue and the prognosis in 218 patients showed that high expression of IGFBP7 was associated with favourable prognosis. Based on above results, we conclude that IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.