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Brief Communication
Metastatic Cancer Cells from c-erbB-2 Negative Primary Breast Cancer Maintain the Original c-erbB-2/HIF1α Phenotype
Alexandra Giatromanolaki, Michael I. Koukourakis, Costantinos Simopoulos and Efthimios Sivridis
volume 6 | issue 2
February 2007Pages: 153 - 155
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The expression of c-erbB-2 and HIF1α proteins is linked with an aggressive tumor phenotype and poor survival in breast cancer. In the present study we investigated whether this ominous effect is a result of c-erbB-2/HIF1α expressing clone appearance within the primary tumor, by examining the c-erbB-2/HIF1α expression status in the primary tumor, node metastasis and cancer cells invading into the lymphovascular spaces. The metastasizing cancer cell clones, whether migrating to the lymph nodes or entering into the systemic circulation maintained the original c-erbB-2/HIF1α phenotype of the primary tumor. Migrating c-erbB-2/HIF1α negative tumors do so through activation of alternative biologic pathways and not through positive clone appearance. These results strongly support the concept that targeted therapies against c-erbB-2 or against HIF1α can be guided with precision by the primary tumor c-erbB-2/HIF1α status without demanding the detection of the metastatic tumor phenotype.
Authors
Alexandra Giatromanolaki
Democritus University of Thrace, Medical School, Alexandroupolis, Greece
Michael I. Koukourakis
Democritus University of Thrace, Medical School, Alexandroupolis, Greece
Costantinos Simopoulos
Democritus University of Thrace, Medical School, Alexandroupolis, Greece
Efthimios Sivridis
Democritus University of Thrace, Medical School, Alexandroupolis, Greece
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.