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Research Paper
Bin1 Attenuation in Breast Cancer is Correlated to Nodal Metastasis and Reduced Survival
Arezoo Ghaneie, Vlasta Zemba-Palca, Hiromichi Itoh, Kaori Itoh, Daitoku Sakamuro, Seigo Nakamura, Alejandro Peralta Soler and George C. Prendergast
volume 6 | issue 2
February 2007Pages: 190 - 194
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Clinical outcomes in breast cancer are likely influenced by modifier genes that affect tumor dormancy versus progression. The Bin1 gene encodes a nucleocytosolic adapter protein that suppresses neoplastic cell transformation and that is often attenuated in human breast carcinoma. Recent mouse genetic studies indicate that Bin1 loss cooperates with ras activation to drive progression of mammary carcinoma, establishing Bin1 as a negative modifier of tumor progression in breast cancer. In this study, we investigated whether immunohistochemical losses of nuclear Bin1 proteins in cases of human breast cancer were correlated to progression status. In American and Japanese groups of low or middle grade breast cancers, losses were associated with reduced survival and increased nodal metastasis, respectively. Taken together with recent findings from mouse genetic studies, these findings encourage further evaluation of the potential utility of Bin1 as a clinical prognostic marker in breast cancer.
Authors
Arezoo Ghaneie
Lankenau Hospital, Wynnewood PA
Vlasta Zemba-Palca
Lankenau Hospital, Wynnewood PA
Hiromichi Itoh
St. Luke’s International Hospital, Tokyo Japan
Kaori Itoh
St. Luke’s International Hospital, Tokyo Japan
Daitoku Sakamuro
LSU School of Medicine, Pathology Department
Seigo Nakamura
St. Luke’s International Hospital, Tokyo Japan
Alejandro Peralta Soler
Duke University School of Medicine, Durham NC USA
George C. Prendergast
Lankenau Institute for Medical Research; Wynnewood Pennsylvania USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.