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Editor's Corner

Cover Image

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In vivo bioluminescent molecular imaging is an emerging powerful tool for accelerating the pace of anti-cancer drug discovery and testing in pre-clinical models. The nude mouse on the cover carried a wild-type p53-expressing human colon xenograft with a stably integrated p53-responsive luciferase reporter gene. The reporter appeared stable and was not silenced as the tumor became established. Injection of exogenous p53 expressed by an adenovirus vector led to detectable increase in luciferase activity within an established tumor (arrow) which was optically imaged by Wang et al. Also see Commentary by Yi Sun.