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Journal Club
Ubiquitination of Myc: Flipping the Switch
Amelie Boquoi and Gregory Enders
volume 5 | issue 8
august 2006Pages: 907 - 908
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Ubiquitination plays a key role in regulating multiple oncoproteins, including those of the Myc-family. A recent Cell paper by Adhikary et al reports that a novel E3 ligase, HectH9, mediates site-specific ubiquitination of Myc and thereby fosters a switch from repression to transcriptional activation. This insight elucidates Myc's diverse properties and provides new targets for the development of anti-cancer therapy.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.