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Research Paper
Preferential Involvement of CX Chemokine Receptor 4 and CX Chemokine Ligand 12 in T-Cell Migration Toward Melanoma Cells
Tianqian Zhang, Rajasekharan Somasundaram, Carol Berking, Laura Caputo, Patricia Van Belle, David Elder, Brian Czerniecki, Susan Hotz, Lynn Schuchter, Francis R. Spitz, Klara Berencsi, Pyapalli Rani, Francesco Marincola, Ruihua Qiu and Dorothee Herlyn
volume 5 | issue 10
october 2006Pages: 1304 - 1312
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Our previous analysis of the role of chemokines in T lymphocyte trafficking toward human tumor cells revealed the migration of a melanoma patient's cytotoxic T lymphocytes (CTL) toward autologous tumor cells, resulting in tumor cell apoptosis, in an organotypic melanoma culture. CTL migration was mediated by CX chemokine receptor (CXCR) 4 expressed by the CTL and CX chemokine ligand (CXCL) 12 secreted by the tumor cells, as evidenced by blockage of CTL migration by antibodies to CXCL12 or CXCR4, high concentrations of CXCL12 or small molecule CXCR4 antagonist. Here, we present the results of T cell migration in one additional melanoma patient and T cell and tumor cell analyses for CXCR4 and CXCL12 expression, respectively, in 12 additional melanoma patients, indicating the preferential role of CXCR4 and CXCL12 in CTL migration toward melanoma cells. These studies add to the increasing body of evidence suggesting that CXCL12 is a potent chemoattractant for T cells.
Authors
Tianqian Zhang
The Wistar Institute, Philadelphia, PA
Rajasekharan Somasundaram
The Wistar Institute, Philadelphia, PA
Carol Berking
The Wistar Institute, Philadelphia, PA
Laura Caputo
The Wistar Institute, Philadelphia, PA
Patricia Van Belle
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
David Elder
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Brian Czerniecki
Hospital of University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Susan Hotz
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Lynn Schuchter
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Francis R. Spitz
University of Pennsylvania, Department of Endocrine and Oncologic Surgery
Klara Berencsi
The Wistar Institute, Philadelphia, PA
Pyapalli Rani
The Wistar Institute, Philadelphia, PA
Francesco Marincola
National Institutes of Health, Bethesda, MD
Ruihua Qiu
The Wistar Institute, Philadelphia, PA
Dorothee Herlyn
The Wistar Institute, Philadelphia, PA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.