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Editor's Corner
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volume 1 | issue 5
September/October 2002Pages: NA A PDF is not yet available for this article.
A yeast-based screen has been designed for temperature-sensitive mutants of BRCA1 in transcription. Transformants carrying BRCA1 with wild-type activity appear as blue colonies (blue arrow) and transformants carrying loss-of-function mutants at 37ยก C appear as white colonies (white arrow). Alvaro Monteiro and colleagues have characterized both synthetic and tumor-derived BRCA1 mutants. Also see Commentary by Jeffrey Parvin.
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