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Research Paper
Detection of BRAF Gene Mutation in Primary Choroidal Melanoma Tissue
Grazia Malaponte, Massimo Libra, Pietro Gangemi, Valentina Bevelacqua, Katia Mangano, Fabio D’Amico, Maria C. Mazzarino, Franca Stivala, , James A. McCubrey and Salvatore Travali
volume 5 | issue 2
february 2006Pages: 225-227
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Numerous BRAF mutations have been detected in melanoma biopsy specimens and cell lines. In contrast, several studies report lack of BRAF mutations in uveal melanoma including primary and metastatic choroidal and ciliary body melanomas. To our knowledge, for the first time, here we report a case of choroidal melanoma harboring the BRAF mutation (V600E). The activation of RAF/MEK/ERK pathway, although independent of BRAF mutation, was reported in uveal melanoma. The presence of V600E mutation indicates that the RAF/MEK/ERK pathway, in addition to cutaneous melanoma progression, may play a role in the choroidal melanoma development.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.