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Research Paper
The SHREW1 Gene, Frequently Deleted in Oligodendrogliomas, Functions to Inhibit Cell Adhesion and Migration
J. Matthew McDonald, Sarah Dunlap, David Cogdell, Valerie Dunmire, Qingyi Wei, Anna Starzinski-Powitz, Raymond Sawaya, Janet Bruner, Gregory N. Fuller, Kenneth Aldape and Wei Zhang
volume 5 | issue 3
march 2006Pages: 300-304
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Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, restoration of SHREW1 expression resulted in suppression of cell adhesion and migration. Thus, SHREW1 inactivation may play a role in the development in oligodendroglial tumors.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.