Research Philosophy

Whose Hypothesis? Ciphering, Sectorials, D Lesions, Freckles and the Operation of Stigler's Law

Volume 1, Issue 5   September/October 2002
Pages 571 - 581
http://dx.doi.org/10.4161/cbt.1.5.225
Authors: Scott E. Kern

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Abstract:
Common references to the famous two-hit hypothesis of tumorigenesis are pervasively erroneous, and the recited tenets of this model vary enormously. Exploration of the history of this model reveals a rich philosophical progression that profited from perceptive observations, clever musings, and rediscoveries by many investigators over a period of decades. The current work is intended to raise the appreciation for this rich history and to address some of the more common errors.

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