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Review
Cancer Specific Viruses and the Development of ONYX-015
Frank McCormick
volume 2
july/august 2003 supplementPages: S157-S160
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Viruses can be engineered to replicate in cancer cells selectively. This can be achieved using regulatory elements with tumor-selectivity, or using deletions of viral genes that are essential in normal cells but dispensable in tumor cells. The latter approach has been used to make viruses that depend on loss of RB or loss of p53. However, redundancy of function of viral proteins and cellular pathways has complicated this approach and required further viral engineering or a better understanding of cellular pathways to increase effectiveness. In spite of these complicating factors, ONYX-015, a prototype of this new class of therapeutic agents, has undergone extensive testing in the clinic, and has proven safe with promising signs of efficacy. Here, I summarize issues relating to selectivity of this agent and its clinical potential. Based on clinical data and new basic discoveries, several approaches are suggested to improve the efficacy of this agent in the clinic.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.