Authors: Xiaokun Hu, Huijuan Qiu, Liang Zhang, Weidong Zhang, Yongqiang Ma, Zhizheng Qiao, Dong Chen, Jianjun Han, Guangfeng Duan and Fujun Zhang

Xiaokun Hu

Department of Medical Imaging and Interventional Radiology; Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University; Guangzhou, Guangdong, China; Department of Interventional Radiology; Pingyi branch of Qilu Hospital; Shandong University; Linyi, Shandong, China

Huijuan Qiu

VIP Region; Cancer Center and State Key Laboratory of Oncology in South China; Sun Yat-sen University; Guangzhou, Guangdong, China

Liang Zhang

Department of Medical Imaging and Interventional Radiology; Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University; Guangzhou, Guangdong, China

Weidong Zhang

Department of Medical Imaging and Interventional Radiology; Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University; Guangzhou, Guangdong, China

Yongqiang Ma

Department of Medical Imaging and Interventional Radiology; Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University; Guangzhou, Guangdong, China; Department of Interventional Radiology; Pingyi branch of Qilu Hospital; Shandong University; Linyi, Shandong, China

Zhizheng Qiao

Department of Interventional Radiology; Pingyi branch of Qilu Hospital; Shandong University; Linyi, Shandong, China

Dong Chen

Department of Medical Imaging and Interventional Radiology; Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University; Guangzhou, Guangdong, China

Jianjun Han

Department of Medical Imaging and Interventional Radiology; Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University; Guangzhou, Guangdong, China

Guangfeng Duan

Department of Medical Imaging and Interventional Radiology; Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University; Guangzhou, Guangdong, China

Fujun Zhang

Corresponding author: zhangfj@sysucc.org.cn
Department of Medical Imaging and Interventional Radiology; Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University; Guangzhou, Guangdong, China

Abstract:
Background: Primary brain tumors have always been associated with high morbidity and mortality. Glioma is the most common type of malignant brain tumors,with a high probability of recurrence after surgical excision and with poor prognosis.The purpose of this study was to compare the therapeutic efficacy of computed tomography (CT)-guided interstitial ¹²⁵I seed implantation with traditional radiochemotherapy for treatment of recurrent gliomas.

Results: The response rate at 1, 3, 6 and 12 months after ¹²⁵I seed implantation was 68.6, 74.3, 77.1 and 62.8% respectively, which was significantly higher than the group treated with the conventional chemoradiation protocol (p < 0.05). Patients exposed to ¹²⁵I seed implantation had a median survival of 29.0 months, whereas the median survival of those treated with traditional radiochemotherapy was 19.0 months. The difference observed between the two groups was significant. There were no severe complications or mortality associated with either treatment, except for one case of intracerebral hemorrhage around the tumor area in the ¹²⁵I seed implants group.

Methods: From November 2002 to May 2010, 73 consecutive patients with recurrent gliomas were treated with CT-guided ¹²⁵I seed implantation (35 cases) or traditional radiochemotherapy (38 cases). Patients were followed up after treatment and the therapeutic effect was evaluated by comparing the response and survival rates of the two groups. In particular, patients treated with ¹²⁵I seed implantation were monitored for adverse side effects.

Received: November 15, 2011; Accepted: May 22, 2012

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