Review

Antiangiogenic agents in the management of non-small cell lung cancer: Where do we stand now and where are we headed?

Volume 13, Issue 5   March 2012
Pages 247 - 263
http://dx.doi.org/10.4161/cbt.19594
Keywords: angiogenesis, antiangiogenic therapy, chemotherapy, monoclonal antibody, non-small cell lung cancer, tyrosine kinase inhibitor, vascular endothelial growth factor
Authors: Charu Aggarwal, Neeta Somaiah and George Simon

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Abstract:
Several therapies targeting angiogenesis are currently in development for non-small cell lung cancer (NSCLC). This review discusses results of recent clinical trials evaluating chemotherapy plus antiangiogenic therapy for NSCLC. Bevacizumab, an anti-VEGF antibody, is currently approved for the treatment of advanced NSCLC in combination with carboplatin and paclitaxel. Completed phase III trials evaluating bevacizumab plus chemotherapy have shown prolonged progression-free survival; however, not all trials showed significant improvement in overall survival (OS). Phase III trials of the tyrosine kinase inhibitors (TKIs) vandetanib and sorafenib and the vascular disrupting agent ASA404 also failed to improve OS compared with chemotherapy alone. Clinical trials are ongoing involving several new antiangiogenic therapies, including ramucirumab, aflibercept, cediranib, BIBF 1120, sunitinib, pazopanib, brivanib, ABT-869, axitinib, ABT-751, and NPI-2358; several of these agents have shown promising phase I/II results. Results from recently completed and ongoing phase III trials will determine if these newer antiangiogenic agents will be incorporated into clinical practice.

Received: September 29, 2011; Accepted: February 3, 2012

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