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Journal Club
Lymphocyte Life and Death: The Caspase-8 Connection
Jun Tang, Holli Kawadler, and Xiaolu Yang
volume 4 | issue 7
july 2005Pages: 700-702
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Caspase-8 plays an important role in death receptor-mediated apoptosis. In contrast to its apoptotic function, recent studies have suggested caspase-8 also plays a role in the immune response, as caspase-8 is essential for lymphocyte proliferation in response to antigen stimulation. In the March 2005 issue of Science (2005; Vol 307, 1465-1468), Su et al. provide compelling evidence supporting a role for caspase-8 in antigen receptor-induced NF-κB activation. They identified caspase-8 as an essential component in the activation of the IKK complex, linking IKK to the upstream Bcl10-MALT1 complex. Intriguingly, they demonstrated that it is not only the physical presence of caspase-8, but rather enzymatic activity that is required for the activation of NF-κB.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.