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Journal Club
A Novel WISp39 Protein Links Hsp90 and p21 Stability to the G2/M Checkpoint
Sharon Benzeno and J. Alan Diehl
volume 4 | issue 4
April 2005Pages: 376-378
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Transcriptional regulation of the p21Cip1 cyclin-dependent kinase inhibitor is a well-established mechanism by which the cell orchestrates a proper spatial and temporal cell cycle progression. Now, in the January 2005 issue of Molecular Cell (2005, Vol 17, 237-249), a study by Jascur et al. identifies a novel multi-protein complex that is critical in contributing to a p53-dependent G2 cell cycle checkpoint. The authors demonstrate the significance of stabilizing the p21 protein in the context of this complex.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.