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Review
Flt-3 Ligand: A Potent Dendritic Cell Stimulator and Novel Antitumor
Jian Dong, Christopher M. McPherson and Peter J. Stambrook
volume 1 | issue 5
September/October 2002Pages: 486-489
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Dendritic cell (DC) vaccination has generated intense interest as a potential cancer therapy. However, the rate limiting step has been the generation of DCs. Flt-3 ligand (FL) is a growth factor that was first discovered by its ability to stimulate the proliferation of hematopoietic progenitor cells of both lymphoid and myeloid origin. The remarkable activity of FL to induce large numbers of dendritic cells both in vivo and in vitro soon captured the interest of numerous researchers. In this review, we examine the structure and function of the FL, its antitumor activity in animal models, and its potential as a novel cancer treatment.
Key Words:
Flt3-L, Dendritic cells, Cell mediated immune response, Cancer therapy
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.