Review

FoxO family members in cancer

Volume 12, Issue 4   August 15, 2011
Pages 253 - 259
http://dx.doi.org/10.4161/cbt.12.4.15954
Authors: Yuqing Zhang, Boyi Gan, Debra Liu and Ji-hye Paik

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Abstract:
The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological processes including cellular energy storage, growth, and survival, among others. As an important effector of this pathway, FoxO is involved in versatile activities that protect organisms from stress and aging. Recent studies on mammalian FoxO have established a direct role for this transcription factor family in cellular proliferation, oxidative stress response, and tumorigenesis. The review will focus on the recent developments pertaining to the function of FoxO as well as discuss the various contexts in which FoxO exerts distinct biological activity such as drug resistance and autophagy in cancer pathogenesis and therapy.

Received: March 30, 2011; Accepted: May 3, 2011

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