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Research Paper
Analysis of Chromosomes 9 and 11 Aneuploidy Frequency in Pleural Effusions of Patients with and without Malignancy: by Interphase FISH Technique
Tülin Cora, Hasan Acar, Sami Ceran, Said Bodur
volume 4 | issue 2
February 2005Pages: 248-251
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Fluids of body cavities result in a series of pathophysiological events associated with nonmalignant and malignant conditions that lead the to formation of exudative effusions. Diagnosis of effusions from the patients is frequently troublesome for the cytologist because of the differentiation and biological behavior of diferrent cells type in effusion. In present study, chromosomal aneuploidy status in effusion cells derived from 32 patients including14 patients with non-malignant and 18 patients with malignant diseases [including malign mesothelioma (n=6), adeno carcinoma (n=10 ), small cell carcinoma (n=2) ] was analysed by using fluorescence in situ hybridization (FISH) with centromere specific probes for chromosomes 9 and 11. There was significant difference in the incidence of chromosomal 9 and 11 aneuploidies when compared with controls (P=0.000). However, aneuploidies of chromosomes 9 and 11 in effusion cells from patients with malignant disease had significantly higher than in effusion cells from patients with nonmalignant (P=0.000), suggesting that chromosomes 9 and 11 are frequently involved in the status of disease. The present study indicates that there is a association between chromosomes aneuploidies and pleural effusion cell status. Chromosome aneuploidies in non-malignant group may be an indicator of premalignancy.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.