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Journal Club
NF-?B: Key Mediator of Inflammation-Associated Cancer
Dara Ditsworth, Wei-Xing Zong
volume 3 | issue 12
december 2004Pages: 1214-1216
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The NF-?B family of transcription factors, well-known for regulating immune and inflammatory responses, has recently been identified as a molecular link between chronic inflammation and cancer. Using distinct models of inflammation-associated cancer, three recent reports now show the importance of NF-?B in promoting cancer progression during inflammation (Greten et al 2004 Cell 118: 285-96, Luo et al 2004 Cancer Cell 6: 297-305, Pikarsky et al 2004 Nature 431: 461-6). Results from these studies suggest that NF-?B exerts its oncogenic effects in both tumor cells and in the tumor microenvironment, promoting the survival of premalignant epithelial cells while also stimulating release of pro-inflammatory mediators from activated macrophages that promote tumor growth.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.