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Focused Review
Chromatin Dynamics and Cancer
Valentina Guasconi and Slimane Ait-Si-Ali
volume 3 | issue 9
september 2004Pages: 825-830
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Chomatin remodelling multi-protein complexes play a key regulatory role in many physiological processes such proliferation and differentiation. The alteration in the recruitment or in the function of one of these chromatin remodelling factors can lead to a proliferation defect, that might result from the aberrant activation or repression of key genes that regulate cell proliferation. In fact, aberrant chromatin remodelling leads to severe human diseases such as leukaemia, epithelial cancers and Rubinstein-Taybi syndrome.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.