• The status of zinc in the development of hepatocellular cancer: An important, but neglected, clinically established relationship
  • Abrogating G<sub>2</sub>/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma
  • Synergistic inhibition of angiogenesis and glioma cell-induced angiogenesis by the combination of temozolomide and enediyne antibiotic lidamycin
  • Antibody-based tumor vascular theranostics targeting endosialin/TEM1 in a new mouse tumor vascular model
  • All-<i>trans</i>-retinoic acid antagonizes the hedgehog pathway by inducing patched

The status of zinc in the development of hepatocellular cancer: An important, but neglected, clinically established relationship

Leslie C Costello and Renty B Franklin

Abrogating G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma

Paola Indovina, Eleonora Marcelli, Domenico Di Marzo, Nadia Casini, Iris Maria Forte, Francesca Giorgi, Luigi Alfano, Francesca Pentimalli and Antonio Giordano

Synergistic inhibition of angiogenesis and glioma cell-induced angiogenesis by the combination of temozolomide and enediyne antibiotic lidamycin

Xing-qi Li, Zhi-gang Ouyang, Sheng-hua Zhang, Hong Liu, Yue Shang, Yi Li and Yong-su Zhen

Antibody-based tumor vascular theranostics targeting endosialin/TEM1 in a new mouse tumor vascular model

Chunsheng Li, Ann-Marie Chacko, Jia Hu, Kosei Hasegawa, Jennifer Swails, Luigi Grasso, Wafik S El-Deiry, Nicholas Nicolaides, Vladimir R Muzykantov, Chaitanya R Divgi and George Coukos

All-trans-retinoic acid antagonizes the hedgehog pathway by inducing patched

Alexander M Busch, Fabrizio Galimberti, Kristen E Nehls, Monic Roengvoraphoj, David Sekula, Bin Li, Yongli Guo, James DiRenzo, Steven N Fiering, Michael J Spinella, David J Robbins, Vincent A Memoli, Sarah J Freemantle and Ethan Dmitrovsky

Current Issue

Cancer Biology & Therapy

August 2014

Volume 15, Issue 8

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About the cover image
Merged confocal images of Bimolecular Fluorescence Complementation (BiFC) results show a functionally relevant interaction between the embryonic stem cell marker protein Zscan4, and the shelterin complex protein Rap, in MCF7 breast cancer cells. DNA was labeled with DAPI (blue), actin filaments were labeled with a fluorescent phalloidin (red). BiFC signal (green) was generated by interaction between human Zscan4, cloned into a pBiFC vector containing half of the GFP fluorophore, and Rap1, cloned into the pBiFC vector containing the other component half. Images were generated under an Olympus APON 60X TIRF NA 1.4 objective. For more information, see Lee and Gollahon, in this issue.

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