Mini-Review

VILIP-1, a Novel Regulator of the Guanylate Cyclase Transduction System in Neurons

Volume 1, Issue 1   January/February/March 2006
Pages 12 - 15
Authors: Karl-Heinz Braunewell, Marian Brackmann and Andreas Hofmann

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Abstract:

VILIP-1 belongs to the subfamily of Visinin-like proteins with its members VILIP-1, -2, -3, hippocalcin and neurocalcin δ which have been implicated in the modulation of a variety of intracellular signalling cascades. VILIP-1 has recently been characterized in more detail and an involvement in cyclic nucleotide signalling has been demonstrated. Thus, similar to other NCS proteins such as GCAPs and neurocalcin δ, VILIP-1 can influence the activtiy of guanylyl cyclase enzymes and the cGMP-signalling system of neurons in the nervous system.

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