Autophagic Punctum

Atg32 Is a tag for mitochondria degradation in yeast

Volume 5, Issue 8   November 16, 2009
Pages 1201 - 1202
http://dx.doi.org/10.4161/auto.5.8.9747
Authors: Tomotake Kanki and Daniel J. Klionsky

View affiliations

Abstract:
The elimination of aged, damaged, or excess mitochondria is an important subcellular event to maintain proper cellular homeostasis. Recent studies reveal that autophagy-dependent degradation of mitochondria (mitophagy) plays an important role to remove these organelles. Very little is known, however, about the molecular mechanism of mitophagy. We found a novel protein, Atg32, that is required for mitophagy but not for other types of selective autophagy or nonselective autophagy. Atg32 is a mitochondrial outer membrane protein. When mitophagy is induced, Atg32 binds to Atg11, an adaptor protein for selective autophagy. Eventually, this interaction results in the recruitment of mitochondria to the vacuole for degradation.

Autophagic Punctum to:
N Isik, JA Brzostowski, T Jin. An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxis. Dev Cell 2008; 15: 590-602
PMID: 19619494 DOI: 10.1016/j.devcel.200

Preview:



Advertisements