Autophagic Punctum

TRB3 links ER stress to autophagy in cannabinoid antitumoral action

Volume 5, Issue 7   October 1, 2009
Pages 1048 - 1049
http://dx.doi.org/10.4161/auto.5.7.9508
Authors: María Salazar, Arkaitz Carracedo, Íñigo J. Salanueva, Sonia Hernández-Tiedra, Ainara Egia, Mar Lorente, Patricia Vázquez, Sofia Torres, Juan L. Iovanna, Manuel Guzmán, Patricia Boya and Guillermo Velasco

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Abstract:
Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, is being investigated as a potential anti-tumoral agent. We find that THC stimulates an endoplasmic reticulum (ER) stress-related signaling pathway, which activates autophagy via inhibition of the Akt/mTORC1 axis. We also show that autophagy is upstream of apoptosis in cannabinoid-induced cancer cell death and that activation of this pathway is necessary for the anti-tumoral action of cannabinoids in vivo.

Autophagic Punctum to:
M Salazar, A Carracedo, IJ Salanueva, S Hernández-Tiedra, M Lorente, A Egia, P Vázquez, C Blázquez, S Torres, S García, J Nowak, GM Fimia, M Piacentini, F Cecconi, PP Pandolfi, L González-Feria, JL Iovanna, M Guzmán, P Boya, G Velasco. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest 2009; 119: 1359-72
PMID: 19425170 DOI: 10.1172/JCI37948

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